Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a combined operation against an subterranean weapons facility in Syrian territory employed by the Islamic State group (IS), as stated by the British defence ministry.
The site, located using intelligence, was believed to be housing weapons and explosive materials, the statement said, and was situated in hills just to the north of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to target a number of entry passages down to the site... early reports suggest the strike was effective," officials stated.
There was no sign of any civilian impact in the operation on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - alternatively referred to as Daesh - established jihadist rule over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates the UK's leading role, and determination to operate in unison with our allies, to eradicate any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," UK Defence Secretary John Healey said.
UK warplanes have performed patrols over Syrian airspace to "deter any attempted resurgence" of Islamic State following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank every member of the UK armed forces participating in this operation for their expertise and their valour," he said. "They were among thousands of UK service members deployed over Christmas and New Year. This action, to eliminate dangerous terrorists who pose a risk to our safety, shows how our armed forces are prepared to act, throughout the year, keeping Britain secure within its borders and strong abroad."
In December, the United States armed forces conducted what it called a "large-scale strike" targeting Daesh sites in Syria, after an attack resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The United Nations says IS still has between 5,000 and 7,000 fighters in Syria and Iraq.